Tissue on a chip
A tissue-on-a-chip is a small, bioengineered platform designed to mimic the functions of human tissue within a microfluidic device. These systems use human primary cells embedded in an extracellular matrix (ECM) to recreate key physiological behaviors such as muscle contraction, drug response, and metabolic activity. Tissue-on-a-chip platforms provide a powerful new approach to model how tissues respond to biochemical signals, electrical inputs, and drugs. By creating human-like tissue models on a chip, researchers can study disease mechanisms and observe real-time cellular behavior in a controlled environment. Data from these experiments allow researchers to model disease progression, test potential countermeasures, and build more accurate tissue-on-a-chip models for biomedical studies both in space and on Earth.
Some examples of tissue-on-a-chip models include:
- Heart on a chip: Simulates cardiac tissue beating and electrical signaling and explores cardiovascular deconditioning in spaceflight.
- Brain on a chip: Replicates neuronal networks and barrier transport.
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